AOD-9604 is a peptide originally developed to aid in fat metabolism and enhance weight loss, offering potential benefits such as improved body composition, reduced body fat, and support for metabolic health without significant adverse effects.
AOD-9604 is a synthetic peptide derived from the C-terminal part of human growth hormone (HGH). Unlike HGH, AOD-9604 is designed to focus on fat metabolism and weight management without causing the anabolic growth effects linked to HGH.
This modified amino acid sequence works by mimicking the fat-burning effects of natural growth hormone, targeting stored fat for energy. Clinical trials have studied its effectiveness for weight loss and its potential to improve metabolic health. Administered through injections, it is gaining attention for helping manage body composition with minimal risk of side effects.
AOD-9604 works by activating the pituitary gland to promote lipolysis, the breakdown of stored fat, while simultaneously suppressing lipogenesis, the creation of new fat. This peptide mimics the activity of the natural growth hormone’s fat-reducing domain, targeting adipose tissue to promote the breakdown of stored fat and its conversion into energy.
Importantly, the peptide achieves these effects without influencing blood sugar levels or promoting muscle growth, which sets it apart from the complete human growth hormone. By acting on fat metabolism pathways, it supports weight management and assists in improving overall metabolic health. This targeted action makes it an appealing option for individuals aiming to reduce body fat without the broader hormonal impacts often associated with HGH therapies.
Molecular Formula: C78H123N23O23S2
Molecular Weight: 1815.1 g/mol
Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH
View our AOD-9604 High-Performance Liquid Chromatography (HPLC) Certificate here.
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Is AOD-9604 legal?
It is legally available in some regions; however, its legality depends on the specific regulations of the country in question. It is important to note that it has not been approved by the FDA for use in humans, which means it is not legally classified as a medication in the United States. Individuals considering its use should consult local laws and seek guidance from a medical professional.
Can AOD-9604 promote muscle growth?
It is not designed to promote muscle growth. Its primary function revolves around fat metabolism and weight management, differing from traditional HGH-based growth peptides.
Are there any side effects associated with AOD-9604?
Potential side effects are minimal but may include localised irritation at the injection site or mild gastrointestinal discomfort. Always consult a professional healthcare provider before commencing any clinical trials.
How safe is AOD-9604?
In six clinical trials, it showed no impact on IGF-1 levels, no adverse effects on carbohydrate metabolism, and no immunogenicity. No serious side effects or withdrawals were reported. Overall, it exhibited a safety and tolerability profile comparable to placebo.
How does AOD-9604 compare to HGH?
Research explored the effects of human growth hormone (hGH) and AOD9604 on weight, fat oxidation, and energy balance in obese and lean mice. Both reduced body weight gain and increased fat oxidation in obese mice, but AOD also promoted fat breakdown without affecting blood sugar or insulin levels. Unlike hGH, AOD does not bind to hGH receptors or trigger cell growth, suggesting it works through different pathways.
Does AOD-9604 suppress appetite?
It primarily targets fat metabolism and body composition but lacks clinical evidence to show it directly suppresses appetite like other weight managment options. Its benefits are focused on fat-burning rather than appetite control.
For more information, explore our latest blog posts dedicated to AOD-9604 peptides.
Buy AOD-9604 peptide San Marino from Direct Sarms, your reliable source for 99% pure research-grade peptides. It’s available in multiple formats, including lyophilized powder (2mg, 5mg, and 10mg vials), 15ml and 30ml nasal sprays, and 2mg pre-mixed pens for added convenience. Designed for laboratory use, AOD-9604 offers exceptional purity and quality to deliver accurate and reliable research results.
Direct Sarms ensures high-quality peptides with precise dosing and reliable results, prioritizing care and consistency for your research needs.
[1] M Heffernan, R J Summers, A Thorburn, E Ogru, et al (2001) The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice – Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9.
[2] M A Heffernan, A W Thorburn, B Fam, R Summers, et al (2001) Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment – International Journal of Obesity Related Metabolism Disorders, 2001 Oct, Volume 25 (Issue 10), Pages 1442-9.
[3] F M Ng, J Sun, L Sharma, R Libinaka, W J Jiang, and R Gianello (2000) Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone – Hormone Research, 2000, Volume 53 (Issue 6), Pages 274-8.
[4] Monika Misra (2013) Obesity Pharmacotherapy: Current Perspectives and Future Directions – Current Cardiology Reviews, 2013 Feb, Volume 9 (Issue 1), Pages 33–54.
[5] Dong Rak Kwon and Gi Young Park (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model – Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issues 4), Pages 426-32.
[6] Heike Stier, Evert Vos, David Kenley (2013) Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans – Journal of Endocrinology and Metabolism, 2013, Volume 3 (Issue 1-2), Pages 7-15.
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