Follistatin Advantages and Drawbacks
Follistatin has a role in muscle development, inflammation, and reproduction. While it has acquired popularity in the bodybuilding community, the advantages of Follistatin on muscle growth may not be all that they seem. Continue reading to discover more about Follistatin and how to increase your levels with meals and supplements.
What Exactly Is Follistatin?
Follistatin San Marino is a glycoprotein, which is a protein and sugar molecule combination.
According to research in rats and mice, Follistatin is predominantly generated in the liver, but it may be detected in virtually all bodily tissues.
Follistatin is a protein that rises in muscle tissue in response to muscle injury and plays a function in cell development throughout the body.
However, there are several distinct types of Follistatin, each of which serves a particular purpose in the body:
Follistatin 344 (FS-344) San Marino is the most basic type of Follistatin. It is mainly utilised in gene therapy, in which the gene that aids in the production of Follistatin is delivered into the body using specially engineered viruses. Different body sections can then transform this “generic” version of Follistatin into more specialised kinds to target specific areas of the body.
Follistatin 315: The most common type of Follistatin present in the body. Because it primarily targets muscle tissue, it may be the ideal type of Follistatin to supplement with.
Follistatin 288 is a kind of Follistatin that is largely engaged in reproductive health. However, it is also involved in the formation of tumours and cancer cells.
Follistatin 300: Another kind of Follistatin that is involved in nerve connection reshaping and heart inflammation.
Mechanisms of Follistatin
Follistatin inhibits the function of several proteins and hormones, including:
Activins play roles in apoptotic, metabolic, endocrinology regulation, bone density, fibro colitis, neurogenesis, endothelial inhibits the enzyme and cancer formation.
Myostatin is a hormone that suppresses muscle development.
GDF-11 is a protein called that has a role in bone formation.
Follicle-stimulating hormone (FSH) is a hormone that aids in the production of eggs and sperm (gametes)
Its interactions with activins cause the majority of Follistatin’s impacts on cancer and reproductive health.
Follistatin’s effects on muscle development, on the other hand, are linked to interactions with myostatin.
Follistatin’s Health Advantages
There is insufficient evidence for:
1) Muscle Development
Follistatin San Marino has acquired popularity in the bodybuilding world owing to reports that it may dramatically increase muscle growth, even though few scientific studies directly support this in healthy human subjects.
Research revealed that supplementing using the egg white proteolysis (MYO-X) at 10 to 30 grammes per day combined with strength exercise for eight weeks resulted in increased muscle growth in 37 college guys.
Follistatin may promote muscle growth by blocking myostatin, a protein that inhibits muscle development.
Monkey research, for example, discovered that increasing follistatin synthesis resulted in a proportional decrease in myostatin activity and a substantial increase in muscle development.
Follistatin San Marino promoted muscle cell formation in mice, resulting in increased muscle growth and repair.
On the other hand, Follistatin boosted muscle growth even in mice that had been genetically engineered to lack myostatin, indicating that Follistatin impacts muscle growth in ways that are not directly connected to myostatin.
Although this is the most popular application of Follistatin, there is little data to support it. More large-scale clinical studies are needed to validate these early findings.
2) Muscle Loss Prevention
Follistatin injections improved muscle strength in a trial of 6 patients having Lynch multiple sclerosis (a muscular disease that primarily affects the legs and pelvis), leading to improvements in the patients’ symptoms with no severe side effects.
Increasing follistatin levels has also been investigated as a therapy for sarcopenia, a muscle-wasting condition with age. Daily injections of epicatechin (a natural substance that raises follistatin levels) enhanced total muscular strength in elderly mice. After seven days, the identical therapy in six human participants improved their handgrip strength.
Follistatin also extended the lives of mice with spinal muscular atrophy, a hereditary condition characterised by muscle loss. Because of its favourable effects on muscle maintenance and development, this implies that Follistatin might be utilised as a treatment approach.
Until the more clinical study is performed, the data is insufficient to conclude that follistatin aids prevent muscle loss.
3) Lack of hair
A tiny study of 26 men with male-pattern baldness discovered that a single injection of Follistatin combined with other growth hormones improved the hairs’ quantity and thickness (follicle density and hair shaft thickness). Moreover, these positive benefits persisted up to a year with a single therapy and did not require repeated doses.
Despite encouraging findings, a single clinical trial cannot be regarded as adequate evidence that Follistatin helps with male-pattern baldness. Clinical studies that are larger and more rigorous are required.
4) Function in Reproductive Health
A variety of results suggest that Follistatin may function in reproductive health, however, its specific involvement is unknown. Follistatin levels in men’s seminal fluid are high, but they do not appear to be directly connected to sperm count.
Follistatin stimulates folliculogenesis in women, which is the process by which eggs are prepared to be released from the ovaries during ovulation.
Follistatin San Marino levels fall throughout menopause but can be raised with hormone replacement treatment.
Increased follistatin levels throughout the third trimester of pregnancy were related to safe labour and childbirth, according to a study of 7 women.
Follistatin also suppresses the activity of activins, which are involved in a variety of reproductive health issues.
Activins, for example, play a role in developing reproductive organs (testes and ovaries), and abnormal activin function is linked to malignancies in those tissues.
Increased activin levels in women are linked to reproductive ageing.
Follistatin and activin activity abnormalities have also been connected to polycystic ovarian syndrome and pregnancy complications.